LSD Microdosing with Dr. James Fadiman and Jordan Gruber
What if one of the most misunderstood and stigmatized substances could actually support mental clarity, emotional balance, and whole-body regulation? In this episode, we explore LSD microdosing with two of the most respected voices in modern psychedelic research: Dr. James Fadiman—often called the father of microdosing—and bestselling author Jordan Gruber. You’ll learn how LSD was discovered, how it actually works in the body, and why microdosing produces such consistent “secondary effects” even after the substance leaves your system.
You’ll also hear the real science behind dosage, safety, and why microdosing behaves more like a vitamin than a symptom-suppressing drug. Dr. Fadiman and Jordan unpack what current evidence shows about mental health, ADHD, SSRI tapering, and why microdoses appear to support whole-system recalibration. Whether you’re curious, cautious, or already exploring microdosing, this conversation offers grounded, research-driven guidance from the very people who pioneered the field.
Listen to the Full Episode:
What You’ll Learn in Today’s Episode:
How LSD was discovered and how it functions in the body.
Why microdosing began with LSD and how the protocol evolved.
What “secondary effects” are and why they matter.
Why LSD microdosing is considered low-risk and non-addictive.
The vitamin-model explanation for whole-body recalibration.
Why taking time off cycles improves results.
How microdosing supports tapering off SSRIs and stimulants.
Differences between microdosing and symptom-suppressing medications.
What current research suggests about safety, benefits, and future applications.
Ideas Worth Sharing:
“Our motto is start low, meaning start below what you think is going to work. And if you have no effects, good, you're in the right range so far. Raise it slowly. Take a couple of cycles before you raise it a little bit. And even with that, even taking it every three days with a low enough dose, the last part of our description is take time off.” - Dr. James Fadiman
“The great thing about microdosing is there is a really high reward-to-risk ratio. Even if it doesn't work for you, generally it's not going to mess you up very badly, and it will quickly stop bothering you as soon as you stop. And yet possible gains are really tremendous.” - Jordan Gruber
“One of the things you learn quickly about psychedelics is, you’re not in control. The fact that most psychedelics are either natural plants or fungi, or derived from natural plants or fungi, suggests that maybe there's a reason why they have these effects.” - Dr. James Fadiman
Resources:
To source SOL, please visit our friends at Golden Rule HERE and use the code KAYSE10 to receive 10% off always.
To purchase James Fadiman and Jordan Gruber's book "Microdosing for Health, Healing & Enhanced Performance" please click HERE.
Dispelling Microdosing Myths with Conor Murray, PhD, in the Flourish Academy
